Breast
cancer type
Breast cancer type is categorized by whether it
begins in the ducts or lobules, the organs responsible for breast milk
production. Medullary carcinoma accounts for 15% of all breast cancer
types. This breast cancer type represents 5% of all diagnosis.
IPR015525 Breast cancer type 2 susceptibility protein Header
EBIDatabasesInterPro Search Open in usermanual InterPro: " />
Jump to: InterProScan Databases Documentation FTP site Help Click on
the icon for context sensitive help from the user manual. The breast
cancer type 2 susceptibility protein (BRCA2) is a breast tumour
suppressor with a potential function in the cellular response to DNA
damage. Some breast cancer types express one or more of these proteins
on their cell surface, while others express none. Media Relations
Contacts Online Press Kit Rumors, Myths, and Truths Glossary About the
American Cancer Society Breastfeeding, Other Factors May Affect Risk of
Breast Cancer TypeAtlanta 2008/08/25 -Factors such as age at menopause
as well as a woman?s breastfeeding practices can influence her risk of
developing certain types of breast cancer.
The investigators found that reproductive risk
factors varied considerably by breast cancer subtype. Their analysis
included 1,023 women with breast cancer whose cells express the
estrogen and progesterone receptors (called luminal cancers), 39 women
with HER2-overexpressing breast cancer, and 78 triple-negative cases
(no expression of estrogen, progesterone, or HER2 receptors). The study
also included 1,476 women without breast cancer. ? They added that
additional studies on the causes of breast cancer subtypes are needed
to better understand the biology of the disease. Learn more about our
commitment to providing complete, accurate, and private breast cancer
information. The study?s results suggest that there are distinct and
separate hormonal risk factors associated with different subtypes of
breast cancer. Women with what is referred to as "triple-negative"
breast cancer are more likely than other women with breast cancer to
experience a relapse, a new study by Canadian researchers shows.
Despite having a high risk of early recurrence, the study indicates
that triple-negative breast cancer patients who remain disease-free for
eight years are unlikely to die of breast cancer and may be "cured" of
their disease.
Breast Feeding Will Lowers Risk Of Breast Cancer
Breastfeeding for 6 months or longer was
associated with a lower risk of luminal cancer as well as
triple-negative cancer, a type that can be particularly aggressive and
difficult to treat. Understanding the specific type of breast cancer
can help you ask better questions and work with your physicians to get
the best breast cancer treatments. For more information on the types
and stages of breast cancer, watch Beyond the Shock®. Medullary
carcinoma accounts for 15% of all breast cancer types. Infiltrating
lobular carcinoma is a type of breast cancer that usually appears as a
subtle thickening in the upper-outer quadrant of the breast. Making up
about 2% of all breast cancer diagnosis, tubular carcinoma cells have a
distinctive tubular structure when viewed under a microscope. Typically
this type of breast cancer is found in women aged 50 and above.
Inflammatory breast cancer is a rare and very aggressive type of breast
cancer that causes the lymph vessels in the skin of the breast to
become blocked.
Breast Cancer Risk
The study's results suggest that there are
distinct and separate hormonal risk factors associated with different
subtypes of breast cancer. Amanda Phipps, a predoctoral research
associate at the Fred Hutchinson Cancer Research Center in Seattle, and
her colleagues conducted a study to better understand the specific risk
factors for the subtypes of breast cancer, which are classified by
expression of the estrogen receptor, the progesterone receptor, and the
HER2 receptor. The investigators found that reproductive risk factors
varied considerably by breast cancer subtype. Breastfeeding for 6
months or longer was associated with a lower risk of luminal cancer as
well as triple-negative cancer, a type that can be particularly
aggressive and difficult to treat. Both late age at menopause and use
of estrogen plus progestin hormone therapy were associated with an
increased risk of luminal disease. Finally, no differences in risks
associated with number of children or the age when a woman first gave
birth were observed by subtype. The study authors concluded that their
results indicate that "certain reproductive factors may have a greater
impact on risk of certain molecular subtypes of disease compared to
others. Despite having a high risk of early recurrence, the study
indicates that triple-negative breast cancer patients who remain
disease-free for eight years are unlikely to die of breast cancer and
may be "cured" of their disease. Insulin resistance, hyperinsulinemia,
and changes in the signaling of growth hormones and steroid hormones
associated with diabetes may affect the risk of breast cancer. Despite
many proposed potential pathways, the mechanisms underlying an
association between diabetes and breast cancer risk remain unclear,
particularly because the 2 diseases share several risk factors,
including obesity, a sedentary lifestyle, and possibly intake of
saturated fat and refined carbohydrates, that may confound this
association. Although the metabolic syndrome is closely related to
diabetes and embraces additional components that might influence breast
cancer risk, the role of the metabolic syndrome in breast
carcinogenesis has not been studied and thus remains unknown.
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